Brooke Simonton

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

This paper introduces Perturb-FISH, a method combining spatial transcriptomics and CRISPR screening to study transcriptional circuits, showing intracellular and intercellular effects in immune and neurological contexts.

Compressed Perturb-seq reduces cost and complexity of CRISPR screens by using random composite perturbations and computational decomposition, achieving similar accuracy to conventional methods with greater power to detect genetic interactions.

The paper introduces CISI, a method that uses compressed sensing to efficiently recover spatial gene expression data from composite measurements, achieving high efficiency and scalability.