Loïc Binan

Simultaneous CRISPR screening and spatial transcriptomics reveals intracellular, intercellular, and functional transcriptional circuits.

This paper introduces Perturb-FISH, a method combining spatial transcriptomics and CRISPR screening to study transcriptional circuits, showing intracellular and intercellular effects in immune and neurological contexts.

Optimization-Based Decoding of Imaging Spatial Transcriptomics Data

The paper introduces JSIT, an optimization-based method for decoding imaging spatial transcriptomics data with lower magnification, improving throughput and recovery performance over standard methods.

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cells

This study develops a rapid, scalable method to generate functional human astrocytes from pluripotent stem cells using NGN2 induction, showing high homogeneity and disease relevance.

Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations

Compressed Perturb-seq reduces cost and complexity of CRISPR screens by using random composite perturbations and computational decomposition, achieving similar accuracy to conventional methods with greater power to detect genetic interactions.