Andrew Daniel Hoffmann

Novel antibody language model accelerates IgG screening and design for broad-spectrum antiviral therapy

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis

The paper identifies a rare subset of CD4 and CD8 double positive T cells that form clusters with circulating tumor cells, promoting cancer metastasis through immune suppression and integrin-mediated interactions.

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment

This paper identifies sequential phases of ETV2-dependent gene expression that drive hematoendothelial fate commitment from mesoderm progenitors.

Hedgehog signaling activates a heterochronic gene regulatory network to control differentiation timing across lineages

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

A Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation

This study identifies a Hedgehog-FGF signaling axis critical for anterior mesoderm patterning during gastrulation using single-cell transcriptomics in Hh-deficient embryos.