Michael F. Wells

The paper introduces a cell village-based fitness screening approach and a Dirichlet regression framework to analyze genetic factors affecting cell proliferation and environmental sensitivity in human neural progenitor cells.

The study compares reprogramming methods for 16p11.2 deletion patient iPSCs and finds no significant differences in their differentiation potential into functional neurons.

The paper identifies a common genetic variant in IFITM3 that explains most inter-individual variation in neural progenitor cell susceptibility to Zika virus using natural genetic variation and synthetic perturbations.

This study shows that TBK1 deficiency in human motor neurons causes TDP-43 proteinopathy through lysosomal dysfunction, and restoring TBK1 rescues the pathology.