Author

Gengle Niu

Harvard UniversityORCID 0000-0002-7609-0618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Atsushi FukudaiD· 1 shared Bianca N. Fernandez· 1 shared Bogdan BudnikiD· 1 shared Brian J. JosephiD· 1 shared Daniel A. MordesiD· 1 shared Francesco LimoneiD· 1 shared Gianluca LazziiD· 1 shared Hadi Mokhtari DowlatabadiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperNeuroscience

Atsushi FukudaORCID

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3 papers

Recent·Most cited

Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation

Omid Sharafi, Timothy Silliman, Hadi Mokhtari Dowlatabad, Gengle Niu, Steven T. Walston, Jean‐Marie C. Bouteiller, Kimberly Kinga Gokoffski, Gianluca Lazzi

This paper investigates how electric field stimulation frequency and waveform shape affect intracellular calcium dynamics in retinal ganglion cells using experimental and computational approaches.

Scientific Reports · Apr 24, 2026Peer-reviewedBioengineering

A negative feedback loop between small GTPase Rap1 and mammalian tumor suppressor homolog KrsB regulates cell-substrate adhesion in Dictyostelium

Yulia Artemenko, Gengle Niu, Megan E. Arnold, Kelsey E. Roberts, Bianca N. Fernandez, Tiffany Flores, Harper D. McClave, Michael Paestella, Jane A. Borleis, Peter N. Devreotes

Molecular Biology of the Cell · Feb 12, 2025Peer-reviewedCell Biology

Loss of TBK1 activity leads to TDP-43 proteinopathy through lysosomal dysfunction in human motor neurons

Jin Hao, Michael F. Wells, Gengle Niu, Irune Guerra San Juan, Francesco Limone, Atsushi Fukuda, Marcel F. Leyton-Jaimes, Brian J. Joseph, Menglu Qian, Daniel A. Mordes, Bogdan Budnik, Zhixun Dou, Kevin C. Eggan

This study shows that TBK1 deficiency in human motor neurons causes TDP-43 proteinopathy through lysosomal dysfunction, and restoring TBK1 rescues the pathology.

bioRxiv · Oct 11, 2021 · PreprintNeuroscience