Structural basis for direct NGF/TrkA blockade by an analgesic antibody
Harsh Bansia, Elisa Damo, Eliezra Glasser, Renato Bruni, Shohei Koide, Nigel W. Bunnett, Amédée des Georges
This paper reports the cryo-EM structure of a TrkA-neutralizing antibody complex, revealing its mechanism of isoform selectivity and therapeutic potential for chronic pain.
bioRxiv · Jul 1, 2026 · PreprintNeuroscience