Elisa Damo

This paper reports the cryo-EM structure of a TrkA-neutralizing antibody complex, revealing its mechanism of isoform selectivity and therapeutic potential for chronic pain.

This study identifies synaptic vesicle endocytosis in nociceptors as a driver of chronic pain and shows that targeting it with CRISPR/dCas9-R via lipid nanoparticles provides long-lasting pain relief without affecting acute pain responses.

This study shows that removing GABAB receptors from oligodendrocyte precursor cells in mice protects against demyelination in spinal cord injury models.

This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.

This study shows that activating β2-adrenergic receptors in microglia with Formoterol reduces neuropathic pain behaviors in mice by inhibiting microglial inflammation and structural changes.