Harsh Bansia

Structural basis for direct NGF/TrkA blockade by an analgesic antibody

This paper reports the cryo-EM structure of a TrkA-neutralizing antibody complex, revealing its mechanism of isoform selectivity and therapeutic potential for chronic pain.

Structural basis of the lobster carapace blue colour mediated by an HPR protein

The paper determines the structure of crustacyanin complexes in American lobster carapace, revealing how HPR proteins contribute to blue coloration through structural tuning of astaxanthin absorption.

Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

The paper reveals how beta-arrestin 1 activates Src kinase via two distinct SH3 domain interactions, using cryo-EM to show structural mechanisms of beta-arrestin-mediated signaling.

Connecting the dots: deep learning-based automated model building methods in cryo-EM

This paper reviews deep learning methods for automating atomic model building in cryo-EM density maps, discussing their classification, limitations, and future directions.

Neuropilin-1 is a co-receptor for NGF and TrkA-evoked pain

This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.