Araven Tiroumalechetty

In vivo characterization of a patient CACNA1A variant reveals paradoxical synaptic effects

The paper characterizes a CACNA1A variant in a patient with mixed clinical symptoms, showing conflicting in vitro and in vivo effects that highlight the importance of cellular context.

WormSNAP: A software for fast, accurate, and unbiased detection of fluorescent puncta in C. elegans

WormSNAP detects and characterizes fluorescent puncta in C. elegans images with a user-friendly tool, offering unbiased and accurate analysis.

Protein-lipid interactions drive presynaptic assembly upstream of cell adhesion molecules

The paper identifies a presynaptic assembly mechanism driven by SYD-1-lipid interactions before neurexin recruitment, showing PIP2-binding residues are critical for active zone formation.

In vivo proximity ligation reveals endogenous candidate interactors of Neurexin's intracellular domain

The paper identifies endogenous interactors of Neurexin's intracellular domain in C. elegans using proximity ligation and mass spectrometry, revealing novel proteins involved in presynaptic function.