Author

Emilio Merheb

Albert Einstein College of MedicineORCID 0000-0002-1415-1075Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Ian M. WillisiD· 2 shared Robyn D. MoiriD· 2 shared Bridget Shafit‐ZagardoiD· 1 shared Craig A. BranchiD· 1 shared E. Richard StanleyiD· 1 shared Juwen C. DuBoisiD· 1 shared Maria E. GulinelloiD· 1 shared Min‐Hui CuiiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersMolecular Biology

Ian M. WillisORCID

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2 papers

Recent·Most cited

Molecular BiologyeLifePeer-reviewedNov 5, 2024

Molecular basis of neurodegeneration in a mouse model of Polr3-related disease

Robyn D. Moir, Emilio Merheb, Violeta Chiţu…·Ian M. Willis

This study develops a mouse model of Polr3-related disease and identifies tRNA pool changes as a causal factor in neurodegeneration.

6 citations

mousebulk RNA-seq

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedSep 28, 2021

Defective myelination in an RNA polymerase IIImutant leukodystrophic mouse

Emilio Merheb, Min‐Hui Cui, Juwen C. DuBois…·Ian M. Willis

This study shows that mutations in Polr3a, a subunit of RNA polymerase III, cause hypomyelination and neurodevelopmental defects in mice, suggesting cell-specific roles for Pol III in oligodendrocyte function.

30 citations

mouseexperimental assay

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