Maria E. Gulinello

This study shows that mutations in Polr3a, a subunit of RNA polymerase III, cause hypomyelination and neurodevelopmental defects in mice, suggesting cell-specific roles for Pol III in oligodendrocyte function.

This study shows that reducing CSF-2 in Csf1r+/- mice rescues behavioral and histopathological deficits in ALSP by preventing microgliosis and transcriptomic changes, suggesting CSF-2 as a therapeutic target.