Robyn D. Moir

This study shows TUDCA reduces drug bioavailability, not directly aiding protein folding, and rescues yeast from ER stress by sequestering toxic compounds.

This study develops a mouse model of Polr3-related disease and identifies tRNA pool changes as a causal factor in neurodegeneration.

This study shows that mutations in Polr3a, a subunit of RNA polymerase III, cause hypomyelination and neurodevelopmental defects in mice, suggesting cell-specific roles for Pol III in oligodendrocyte function.

The paper evaluates the functional impact of Polr3a mutations associated with hypomyelinating leukodystrophy by engineering them into the yeast homolog Rpc160 and analyzing their effects on transcription.

This study shows MAF1 represses RNA polymerase III transcription in mice, affecting nucleotide demand and metabolism across fasting and refeeding conditions.

The paper presents a cryo-EM structure of yeast Maf1 bound to Pol III, revealing how Maf1 represses transcription by sequestering initiation elements and blocking the active site.