Author

Juwen C. DuBois

Albert Einstein College of MedicineORCID 0000-0002-2905-9837Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Bridget Shafit‐ZagardoiD· 2 shared Craig A. BranchiD· 1 shared Emilio MerhebiD· 1 shared Hillary M. GuzikiD· 1 shared Ian M. WillisiD· 1 shared James E. GoldmaniD· 1 shared John R. CorboyiD· 1 shared Maria E. GulinelloiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Bridget Shafit‐ZagardoORCID

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2 papers

Recent·Most cited

TMEM106B is increased in Multiple Sclerosis plaques, and deletion causes accumulation of lipid after demyelination

Bridget Shafit‐Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary M. Guzik, Sarah Graff, Rashed M. Nagra

This study identifies TMEM106B as an insoluble protein increased in MS plaques and shows its deletion causes axonal damage and lipid accumulation in demyelination models.

bioRxiv · May 5, 2022 · PreprintNeuroscience

Defective myelination in an RNA polymerase IIImutant leukodystrophic mouse

Emilio Merheb, Min‐Hui Cui, Juwen C. DuBois, Craig A. Branch, Maria E. Gulinello, Bridget Shafit‐Zagardo, Robyn D. Moir, Ian M. Willis

This study shows that mutations in Polr3a, a subunit of RNA polymerase III, cause hypomyelination and neurodevelopmental defects in mice, suggesting cell-specific roles for Pol III in oligodendrocyte function.

Proceedings of the National Academy of Sciences · Sep 28, 2021Peer-reviewedNeuroscience