Author

Jacob E. Aronoff

Arizona State UniversityORCID 0000-0002-1422-801XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:clinical cohort / trial· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Benjamin C. TrumbleiD· 2 shared Alan Arthur CoheniD· 1 shared Maximilien FranckiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersEvolutionary Biology

Benjamin C. TrumbleORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintJun 5, 2026

Inflammaging mediates testosterone declines in men while maintaining high testosterone increases mortality risk

Jacob E. Aronoff, Benjamin C. Trumble

This study shows that inflammaging mediates age-related testosterone declines in men and that high testosterone with inflammation increases mortality risk.

DOI 10.64898/2026.06.04.730222

humanstatistical model

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintOct 17, 2025

Evidence for an energetic trade-off model linking inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank

Jacob E. Aronoff, Maximilien Franck, Alan Arthur Cohen, Benjamin C. Trumble

The paper examines an energetic trade-off model linking inflammaging and immunosenescence using data from the US Health and Retirement Study and UK Biobank, finding evidence of TNFR1 and GDF15 mediating age-related immune declines and health risks.

DOI 10.1101/2025.10.17.682903

humanclinical cohort / trial

𝕏 PostBluesky