Alan Arthur Cohen

This paper shows DE-SWAN is unreliable for studying aging rate changes due to sensitivity to age distribution and model parameters.

The paper develops an ISRGDF15 index to quantify the GDF15 arm of the ISR in human cells and tissues, showing its upregulation in specific tissues and correlation with age.

The paper examines an energetic trade-off model linking inflammaging and immunosenescence using data from the US Health and Retirement Study and UK Biobank, finding evidence of TNFR1 and GDF15 mediating age-related immune declines and health risks.

The paper examines mitochondrial distribution patterns across tissues and finds they lack coherence, suggesting tissue-specific and individualized regulatory mechanisms.

The paper develops three computational pipelines to analyze longitudinal saliva proteomics data and identifies significant differences in proteome dynamics between healthy controls and mitochondrial disease patients.

The paper identifies 280 alternative proteins in human protein-protein interaction networks using proteogenomic data and experimental validation, revealing new interactions and functional roles.

This study uses nutritional geometry to analyze how dietary patterns affect aging in 1560 older adults, finding that optimal nutrient levels are often intermediate and context-dependent.

This study investigates frailty as an emergent property of physiological system dysregulation using Mahalanobis distance in two older adult cohorts, finding partial support for breadth and nonlinearity of associations.

The paper compiles healthspan-related gene pathways in C. elegans and humans using literature review and molecular interaction data, identifying common themes like transcription and lipids.