Selective Glucocorticoid Receptor Modulators of Immune Checkpoint Function
Robin R. Kobylski, Charles K. Min, Jerome C. Nwachukwu, Marcel Koenig, Haotian Zhang, Lizbeth Moncada, Thomas Venables, Bin-Bin Schell, William J. Stein, Claudia McCown, Justin Shumate, Emilie Bonilla, Amin Sobh, Arantxa Romero-Toledo, Matthew E. Pipkin, , K.W. Nettles
The paper develops selective glucocorticoid receptor modulators (SGRMs) that modulate immune checkpoint function by altering GR activity states through structural design and machine learning.
bioRxiv · Feb 4, 2026 · PreprintSystems Biology