Clement C.H. Zai

This study uses Mendelian randomization and mediation analysis to show that neuroticism's link to Alzheimer's disease is mediated by modifiable factors like depression, hypertension, and alcohol consumption, rather than being causal.

The paper introduces a Nextflow workflow for local ancestry-aware GWAS, demonstrating its utility in analyzing admixed individuals and identifying ancestry-specific genetic associations.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study compares computational models of approach-avoidance biases in suicidal populations using hierarchical Bayesian inference, finding that simpler models with value decay better explain behavior than complex ones.

This study evaluates LAI performance in admixed populations, finding reduced accuracy for Amerindigenous tracts and highlighting the importance of reference panel matching.

This study performs the largest GWAS of tardive dyskinesia, identifies novel and suggestive loci, and explores polygenic risk and biological pathways.

This study finds frequent copy number variant (CNV) syndromes in schizophrenia patients and proposes a CNV-schizophrenia model linking specific phenotypes to CNVs.

Cross-disorder meta-analysis of eight psychiatric GWAS (232,964 cases, 494,162 controls) reports 109 loci shared by two or more disorders and three groups of correlated disorders.

This paper conducts a GWAS on suicide attempt across psychiatric disorders, identifying genetic loci and showing polygenic risk for major depression predicts suicide attempt in multiple disorders.