Eduardo D. Gigante

This study shows that ciliary ARL13B in the nervous system is essential for body weight regulation in mice, as its disruption leads to obesity and metabolic dysfunction.

The paper validates CRISPR/Cas9 guide RNAs for eight neurodevelopmental genes in Ciona robusta, showing varying mutagenesis efficacy and improved correlation with RS3 scores.

The paper shows that neuropeptide tachykinin and Wnt signaling regulate cardiomyocyte progenitor proliferation in Ciona robusta, with neuronal innervation playing a key role.

The paper identifies regulatory factors required for specifying post-metamorphic branchiomeric neurons in tunicates and shows larval differentiation of adult neurons.

This study shows that ARL13B in cilia inhibits kidney cyst formation in mice, and this function is independent of its role as a GEF for ARL3.

This study shows that ARL13B's function outside cilia is critical for Sonic Hedgehog signaling, while its role within cilia is dispensable for Shh transduction.