PhysiologySciencePeer-reviewed
Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension
Lloyd D. Harvey, Mona Alotaibi, Yi‐Yin Tai…·Stephen Y. Chan
The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.