Tomoya Eguchi

This study quantifies basal autophagic flux in mice using GFP-LC3-RFP reporter mice, revealing higher flux in brain, liver, and kidney compared to other tissues.

The paper identifies bi-allelic ATG12 variants causing a neurodevelopmental disorder by impairing autophagy, with clinical and functional evidence from patient cells, yeast, and zebrafish models.

This paper develops optogenetic tools to induce membrane rupture of specific organelles using engineered BAX proteins with light-sensitive domains.

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

The paper investigates how lysosomotropic agents enhance LRRK2-mediated Rab10 phosphorylation under lysosomal stress conditions.