Rabia Bouali‐Benazzouz

The paper introduces Spinotrode, a vertebral implant for long-term single-cell recordings in the dorsal horns of behaving mice, revealing new insights into spinal neuron dynamics during natural behaviors.

This study shows that NRM serotonergic neurons bidirectionally control spinal nociception through different 5-HT receptors, with 5-HT2c mediating analgesia and 5-HT3 causing hyperalgesia.

The paper identifies a circuit mechanism involving SST+ vlPAG cells projecting to the RVM that regulate analgesia during defensive states in mice.