Nucleus raphe magnus serotonin neurons bidirectionally control spinal nociceptive transmission in mice
Zoé Grivet, Aude Verboven, Franck Aby, Rabia Bouali‐Benazzouz, Thibault Dhellemmes, Emma Perrot, Anna Beyeler, Lora K. Heisler, Maddalena Balia, Arne Battefeld, Hugo Martin, Aude Retailleau, François Maingret, Xavier Fioramonti, Marc Landry, , Pascal Fossat
This study shows that NRM serotonergic neurons bidirectionally control spinal nociception through different 5-HT receptors, with 5-HT2c mediating analgesia and 5-HT3 causing hyperalgesia.
bioRxiv · Apr 9, 2025 · PreprintNeuroscience