Heather E. Machado

The paper reports mutation rates and mutational signatures across 53 normal human cell types, revealing variation in mutation accumulation and identifying known and unknown mutational processes.

The paper identifies somatic TYK2 mutations in TILs that enhance anti-cancer immunity and shows their therapeutic potential through mouse models.

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

The paper develops a bioinformatics pipeline to integrate Drosophila melanogaster genomic data from diverse sources, creating a large dataset called DEST for population genetics analysis.

The paper analyzes the mutational landscape of normal lymphocytes, revealing off-target effects of programmed genome engineering and the impact of differentiation and microenvironment exposure.

The paper updates metadata for four misidentified samples in the DrosRTEC dataset using PCA and DAPC analysis of published datasets.

The paper uses deep genomic sequencing in Drosophila to quantify selection on synonymous sites, finding strong codon usage bias selection that challenges the Li-Bulmer model.