This study uses Cav1.3-C-terminus gene therapy to restore electrophysiological and contractile functions in hiPSC-derived cardiomyocytes with ET-1-induced heart failure.

bioRxiv · Oct 28, 2026 · PreprintCell Biology

Validation of differentiated sinoatrial-like hiPSCs as a model of native sinus node myocytes

Eleonora Torre, Yvonne Sleiman, Haikel Dridi, Azzouz Charrabi, Nadia Mekrane, Giuseppe Angelini, Leïla Talssi, Rajesh Kumar Soni, Valentina Di Biase, Héloïse Faure-Gautron, Pascal Seyer, Pieter P. de Tombe, Andrew R. Marks, Jean‐Luc Pasquié, Alain Lacampagne, , Albano C. Méli

The paper validates a protocol to generate sinoatrial-like hiPSC-derived cardiomyocytes that mimic native SAN myocytes in function and protein expression.

bioRxiv · Jan 23, 2026 · PreprintCell Biology

Modeling Sympathetic Neuro-Cardiac Interactions in a hiPSC-Based Microphysiological System

Jean‐Baptiste Reisqs, Yvonne Sleiman, Mohamed Boutjdir

This paper develops a microphysiological system using hiPSC-derived neurons and cardiomyocytes to model sympathetic neuro-cardiac interactions and test drug effects.

Lab on a Chip · Jan 1, 2026Peer-reviewedPhysiology

Electrophysiological abnormalities associated with a CACNA1D variant are rescued by AAV6-Cav1.3-C-terminus gene therapy in patient-iPSC-CMs

Jean‐Baptiste Reisqs, Yvonne Sleiman, Ivan Gando, Michael Cupelli, Vamsi Krishna Murthy Ginjupalli, Hélène Delanoë‐Ayari, William A. Coetzee, Yongxia Sarah Qu, Mario Delmar, Frank Cecchin, Reina Bianca Tan, Mohamed Chahine, Mohamed Boutjdir

This study shows that a CACNA1D variant causes electrophysiological abnormalities in hiPSC-CMs, which are reversed by AAV6-Cav1.3-C-terminus gene therapy.

bioRxiv · Dec 17, 2025 · PreprintPhysiology