Kaiyun Guan

This paper introduces a three-factor mathematical model to explain symmetry breaking and the n-1 rule in X-chromosome inactivation by integrating Xist, an X-linked activator, and SPEN.

This study shows ratiometric signaling allows cells to integrate temporal receptor activity for accurate gradient sensing despite noise.

The paper identifies Pak1 as a key protein mediating negative feedback in yeast to enable multiple polarity sites and budding.