Cancer BiologyCancer DiscoveryPeer-reviewed
Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma
Imran Noorani, Magnus J. Haughey, Jens Luebeck…·Benjamin Werner
This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.
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