Author
Memorial Sloan Kettering Cancer CenterORCID 0000-0002-8649-7817Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Maira Di Tano, Mujmmail Ahmed, Shiri Li…·Marcus DaSilva Goncalves
The paper shows BRCA2 loss leads to a PKM1-dominant glycolytic state that can be targeted with PKM activators to kill HRD tumors.
Minsi Zhang, Ziqi Jiao, Ylenia Cendon Florez…·Gaspare La Rocca
The paper shows that inhibiting the HMWR complex causes mitotic defects and enhances cancer cell vulnerability when combined with genotoxic agents.
Imran Noorani, Magnus J. Haughey, Jens Luebeck…·Benjamin Werner
This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.
Lotte Brückner, Robin Xu, Jun Tang…·Anton George Henssen
This study shows that ecDNA mis-segregation leads to micronuclei formation, reduced oncogene transcription, and improved patient survival in neuroblastoma.