Extrachromosomal DNA driven oncogene spatial heterogeneity and evolution in glioblastoma
Imran Noorani, Magnus J. Haughey, Jens Luebeck, Andrew Rowan, Eva Camilla Gronroos, Francesco Terenzi, Ivy Tsz-Lo Wong, Davide Pradella, Marta Lisi, Jeanette Clarissa Kittel, Natasha Sharma, Chris Bailey, Clare E. Weeden, Donald M. Bell, Eric Joo, , Benjamin Werner
This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.
Cancer Discovery · Sep 8, 2025Peer-reviewedCancer Biology