The CCR4/CCL17 axis drives intestinal acute Graft versus Host disease after allogeneic bone marrow transplantation
Sebastian Schlaweck, Michelle Klesse, Oliver Schanz, Selina K. Jorch, Glen Kristiansen, Marieta Ioana Toma, Chrystel Flores, Janine Becker-Gotot, Christian Kurts, Peter Brossart, Dominik Georg Friedrich Wolf, Annkristin Heine
This study shows that the CCR4/CCL17 axis promotes intestinal acute GvHD by recruiting T cells and increasing Gata3 expression, and identifies ruxolitinib as a potential therapeutic.
bioRxiv · Mar 2, 2024 · PreprintImmunology