XPO1 Inhibition by Selinexor Induces Nuclear p53 and p21 Accumulation, Cell-Cycle Arrest and Apoptosis in Testicular Germ Cell Tumors
Rashidul Islam, Anne Wladhaus, Isabella Federica Bollen…·Hubert Schorle
This study shows selinexor, an XPO1 inhibitor, reduces viability and induces cell-cycle arrest and apoptosis in testicular germ cell tumors by increasing nuclear p53 and p21.