BiochemistrySciencePeer-reviewed
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Mitochondrial control of fuel switching via carnitine biosynthesis
Christopher Auger, Hiroshi Nishida, Bo Yuan…·Shingo Kajimura
SLC25A45 is the inner mitochondrial membrane transporter for trimethyllysine required for de novo carnitine biosynthesis, enabling metabolic fuel switching to fatty acid oxidation during cold exposure and semaglutide treatment.