Shingo Kajimura

The paper identifies a cell-intrinsic cold-sensing mechanism that enhances lipolysis through phase separation of perilipin 1 in adipose tissue.

This study identifies SLC25A34 as a fasting-inducible mitochondrial carrier that mediates PEP import, linking amino acid catabolism to muscle preservation during fasting.

This study identifies BAT-derived metabolites that protect the liver from oxidative stress by remodeling the circulating metabolome.

This study identifies E4BP4 as a transcriptional repressor that prevents obesity-induced mitochondrial fragmentation in brown fat by inhibiting ceramide synthesis, improving glucose homeostasis without weight loss.

This study identifies SLC25A35 as a mitochondrial PEP transporter that regulates glycerolipid synthesis in lipogenic cells, with implications for metabolic diseases.

SLC25A45 is the inner mitochondrial membrane transporter for trimethyllysine required for de novo carnitine biosynthesis, enabling metabolic fuel switching to fatty acid oxidation during cold exposure and semaglutide treatment.

The paper shows that gap junctions between breast cancer cells and adipocytes transfer cAMP, activating lipolysis in the tumor microenvironment to support tumor growth.

This study shows that sympathetic neuron-derived NPY sustains mural progenitors of thermogenic adipocytes, protecting against obesity by maintaining thermogenic capacity.

This study shows ZIP13 regulates lipid metabolism by modulating intracellular iron and zinc balance in adipocytes.

This study shows that loss of Coq10a, a muscle-enriched mitochondrial protein, enhances postnatal cardiac hypertrophy without impairing cardiac function.