Author

Mike R. Dekker

Erasmus MCORCID 0000-0002-1580-1359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

Pelicano de Almeida MarianaiD· 2 shared Raymond A. PootiD· 2 shared Wilfred F. J. van IJckeniD· 2 shared Alessandro VitrioloiD· 1 shared Anke Van DijckiD· 1 shared Anne L. Kuijpers-Korporaal· 1 shared Anneke T. Vulto‐van SilfhoutiD· 1 shared Bert B A De VriesiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Pelicano de Almeida MarianaORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 6, 2025

Disruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndrome

Ludovico Rizzuti, Alessandro Vitriolo, Pelicano de Almeida Mariana…·Giuseppe Testa

This study identifies the ADNP-KDM1A-GTF2I complex as critical for neural differentiation balance in HVDAS by repressing transposable elements and regulating gene transcription.

DOI 10.1101/2025.03.06.641037

humanbulk RNA-seq

𝕏 PostBluesky

Developmental BiologybioRxivPreprintNov 26, 2024

The Integrator complex prevents premature neuronal differentiation through global control of transcription elongation.

Hedda B. Somsen, Kristel N. Eigenhuis, Anne L. Kuijpers-Korporaal…·Debbie L.C. van den Berg

The paper shows that the Integrator complex regulates neuronal differentiation by controlling RNA polymerase II pause-release, and that disrupting this process leads to premature neuronal gene expression and developmental defects.

DOI 10.1101/2024.11.26.625369

humanbulk RNA-seq

𝕏 PostBluesky