Author

Hedda B. Somsen

Erasmus MCORCID 0000-0002-9481-2813Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Anne L. Kuijpers-Korporaal· 1 shared Danny HuylebroeckiD· 1 shared Debbie L.C. van den BergiD· 1 shared K. Peter Kats· 1 shared Kristel N. EigenhuisiD· 1 shared Maarten W.J. FornerodiD· 1 shared Mariana Pelicano de AlmeidaiD· 1 shared Mike R. DekkeriD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperDevelopmental Biology

Anne L. Kuijpers-Korporaal

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1 paper

Recent·Most cited

The Integrator complex prevents premature neuronal differentiation through global control of transcription elongation.

Hedda B. Somsen, Kristel N. Eigenhuis, Anne L. Kuijpers-Korporaal, Mariana Pelicano de Almeida, Roberto Montoro Ferrer, K. Peter Kats, Mike R. Dekker, Thuur Zuidweg, Zakia Azmani, Mirjam C. G. N. van den Hout, Wilfred F. J. van IJcken, Danny Huylebroeck, Maarten W.J. Fornerod, Raymond A. Poot, Debbie L.C. van den Berg

The paper shows that the Integrator complex regulates neuronal differentiation by controlling RNA polymerase II pause-release, and that disrupting this process leads to premature neuronal gene expression and developmental defects.

bioRxiv · Nov 26, 2024 · PreprintDevelopmental Biology