Homayoun Valafar

This study shows pregnancy alters sleep-wake patterns and reduces kynurenine-induced REM sleep disruption in female rats, suggesting KP metabolism influences maternal sleep.

This study shows that maternal sleep fragmentation and inflammation increase fetal brain kynurenic acid, linking sleep disruption to neurodevelopmental risks.

The paper uses PDBMine and machine learning to improve protein structure validation, enhancing model reliability for drug discovery.

The paper investigates how inhibiting kynurenine aminotransferase II (KAT II) affects sleep disturbances caused by kynurenine in rats.

This study shows that inhibiting KAT II reduces KYNA levels, improving sleep quality in rats exposed to embryonic kynurenine and in controls.

The paper introduces REDCRAFT, a software package that determines protein structures from RDC data alone, successfully applying it to proteins of varying sizes and demonstrating its accuracy compared to NOE-based methods.