Author

Norma Frizzell

University of South CarolinaORCID 0000-0002-5080-4176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ana PocivavsekiD· 3 shared Courtney J. WrightiD· 2 shared Homayoun ValafariD· 2 shared J Hunter Cox· 2 shared Maria V. Piroli· 2 shared Snezana Milosavljevic· 2 shared Aliaksandra SikirzhytskayaiD· 1 shared B. Celia CuiiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Ana PocivavsekORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pregnancy Impacts Maternal Sleep: Focus on Kynurenine Pathway Activation in Female Rats

Courtney J. Wright, Maria V. Piroli, J Hunter Cox, Homayoun Valafar, Norma Frizzell, Ana Pocivavsek

This study shows pregnancy alters sleep-wake patterns and reduces kynurenine-induced REM sleep disruption in female rats, suggesting KP metabolism influences maternal sleep.

bioRxiv · Sep 21, 2026 · PreprintNeuroscience

Fragmented sleep during pregnancy induces inflammation and tryptophan-kynurenine pathway metabolism: Importance of elevated fetal brain kynurenic acid

Courtney J. Wright, J Hunter Cox, Snezana Milosavljevic, Homayoun Valafar, Norma Frizzell, Ana Pocivavsek

This study shows that maternal sleep fragmentation and inflammation increase fetal brain kynurenic acid, linking sleep disruption to neurodevelopmental risks.

bioRxiv · Jun 29, 2026 · PreprintNeuroscience

Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring

Snezana Milosavljevic, Maria V. Piroli, Emma J Sandago, Gerardo G. Piroli, Holland H Smith, Sarah Beggiato, Norma Frizzell, Ana Pocivavsek

This study shows that parental Kmo genotype affects offspring behavior and sleep in sex-specific ways through changes in the kynurenine pathway and brain mitochondrial function.

Biology of Sex Differences · Apr 2, 2025Peer-reviewedNeuroscience

Suppression of HIV and cocaine-induced neurotoxicity and inflammation by cell penetrable itaconate esters

B. Celia Cui, Marina V Aksenova, Aliaksandra Sikirzhytskaya, Diana Akinyi Odhiambo, Elizaveta Korunova, Vitali Sikirzhytski, Hao Ji, Diego Altomare, Eugenia V. Broude, Norma Frizzell, Rosemarie M. Booze, Michael D. Wyatt, Michael S. Shtutman

This paper shows that 4-octyl-itaconate reduces HIV and cocaine-induced neurotoxicity and inflammation by modulating microglial activity and anti-inflammatory pathways.

bioRxiv · Sep 25, 2023 · PreprintNeuroscience