Ana Pocivavsek

Pregnancy Impacts Maternal Sleep: Focus on Kynurenine Pathway Activation in Female Rats

This study shows pregnancy alters sleep-wake patterns and reduces kynurenine-induced REM sleep disruption in female rats, suggesting KP metabolism influences maternal sleep.

Fragmented sleep during pregnancy induces inflammation and tryptophan-kynurenine pathway metabolism: Importance of elevated fetal brain kynurenic acid

This study shows that maternal sleep fragmentation and inflammation increase fetal brain kynurenic acid, linking sleep disruption to neurodevelopmental risks.

Biochemical Regulation of Brain Kynurenic Acid Synthesis and Inhibition in Rats is Sensitive to the Time of Day

This study investigates how time of day affects kynurenic acid (KYNA) synthesis and inhibition in rats, showing phase-dependent changes in KYNA levels and KAT II enzyme activity.

Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring

This study shows that parental Kmo genotype affects offspring behavior and sleep in sex-specific ways through changes in the kynurenine pathway and brain mitochondrial function.

The sleep quality- and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the enzyme

This paper investigates the impact of the PDE11A-Y727C variant on neural physiology, showing reduced catalytic activity and altered subcellular compartmentalization without significant effects on eye growth or sleep quality.

Reducing brain kynurenic acid synthesis precludes kynurenine-induced sleep disturbances

The paper investigates how inhibiting kynurenine aminotransferase II (KAT II) affects sleep disturbances caused by kynurenine in rats.

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult

This study shows that inhibiting KAT II reduces KYNA levels, improving sleep quality in rats exposed to embryonic kynurenine and in controls.

Estradiol Influences Adenosinergic Signaling and NREM Sleep Need in Adult Female Rats

This study investigates how estradiol affects adenosinergic signaling and NREM sleep need in adult female rats, finding that estradiol increases extracellular adenosine and blocks A2A receptor effects in the MnPO.