Author

Tomohiro Noguchi

Collaborative Research Institute for Innovative Microbiology, The University of TokyoORCID 0000-0002-1594-3007Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Tomohiro Noguchi1 paper · Tokyo University of Agriculture

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Kazuo Shin‐yaiD· 1 shared Mitsuo UmetsuiD· 1 shared Nur Syatila Ab GhaniiD· 1 shared Sakiya KawadaiD· 1 shared Takuma Matsushita· 1 shared Tomohisa KuzuyamaiD· 1 shared Tomoyuki ItoiD· 1 shared Yoichi KurumidaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Kazuo Shin‐yaORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintAug 7, 2026

Evaluating Lightweight and Full Fine-Tuning Strategies Against Classical Machine Learning for Protein Function Prediction

Nur Syatila Ab Ghani, Takuma Matsushita, Tomohiro Noguchi…·Yutaka Saitō

This study compares different fine-tuning strategies and classical machine learning approaches for protein function prediction using benchmark datasets.

DOI 10.64898/2026.08.02.737389

protein sequencemachine learning (classical)

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BiochemistrybioRxivPreprintJun 23, 2026

A PLP-Dependent Decarboxylative Mannich Reaction Initiates Construction of the Nonpeptidic Scaffold of Kaitocephalin

Tomohiro Noguchi, Yukari Maeno, Kazuo Shin‐ya, Tomohisa Kuzuyama

This paper identifies KpbH as a PLP-dependent enzyme that catalyzes a decarboxylative Mannich-type reaction to construct a nonpeptidic scaffold in Kaitocephalin biosynthesis.

DOI 10.64898/2026.06.22.733665

experimental assay

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