Tomohisa Kuzuyama

This paper identifies KpbH as a PLP-dependent enzyme that catalyzes a decarboxylative Mannich-type reaction to construct a nonpeptidic scaffold in Kaitocephalin biosynthesis.

The paper predicts protein-protein interactions in biosynthetic gene clusters to uncover hidden molecular networks and functional enzyme complexes.

This paper introduces a transformer-based model for predicting and designing biosynthetic gene clusters, achieving high accuracy in domain prediction and validating novel gene clusters through experimental testing.

This paper identifies the biosynthetic gene cluster for kaitocephalin in Eupenicillium shearii and characterizes key enzymes involved in its unique non-peptidic scaffold formation.

The paper investigates RNase T2's role in ribosome autophagy in yeast, showing Rny1p's function in rRNA degradation and its importance for starvation adaptation.

The paper reveals how hibernating ribosomes inhibit RNase I activity to regulate rRNA degradation and biofilm formation in E. coli.