Author

Kazuo Shin‐ya

National Institute of Advanced Industrial Science and TechnologyORCID 0000-0002-4702-0661Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Assay:metabolomics· 1

Frequent Co-Authors

Tomohisa KuzuyamaiD· 2 shared Yukari MaenoiD· 2 shared Jun‐ichi MaruyamaiD· 1 shared Naoya Saito· 1 shared Taro ShiraishiiD· 1 shared Tomohiro NoguchiiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

Tomohisa KuzuyamaORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 23, 2026

A PLP-Dependent Decarboxylative Mannich Reaction Initiates Construction of the Nonpeptidic Scaffold of Kaitocephalin

Tomohiro Noguchi, Yukari Maeno, Kazuo Shin‐ya, Tomohisa Kuzuyama

This paper identifies KpbH as a PLP-dependent enzyme that catalyzes a decarboxylative Mannich-type reaction to construct a nonpeptidic scaffold in Kaitocephalin biosynthesis.

DOI 10.64898/2026.06.22.733665

experimental assay

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BiochemistryAngewandte Chemie International EditionPeer-reviewedFeb 10, 2026

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide-Like yet Non-Peptidic Scaffold

Yukari Maeno, Taro Shiraishi, Naoya Saito…·Tomohisa Kuzuyama

This paper identifies the biosynthetic gene cluster for kaitocephalin in Eupenicillium shearii and characterizes key enzymes involved in its unique non-peptidic scaffold formation.

2 citationstop 4%

fungi (other)metabolomics

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