Author

Jean‐Paul L. Wiegand

University of ArizonaORCID 0000-0002-0385-1527Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam C. RaikesiD· 1 shared Angel C Leslie· 1 shared Avnish BhattraiiD· 1 shared Carolina Figueroa· 1 shared David Robert BradfordiD· 1 shared Dhanalakshmi Chinnasamy· 1 shared Elsa M. Reyes‐ReyesiD· 1 shared Fabian‐Xosé FernandeziD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Adam C. RaikesORCID

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2 papers

Recent·Most cited

NeuroscienceFrontiers in NeurosciencePeer-reviewedJul 14, 2026

Humanized APOE mouse brain volume increases over age irrespective of sex and APOE genotype: Implications for translational validity to the human

Adam C. Raikes, Avnish Bhattrai, Tian Wang…·Roberta Dı́az Brinton

The paper analyzes brain volume changes in humanized APOE mice across age and genotype, finding age-related increases in total brain volume and no significant sex or genotype differences in localized volume changes.

2 citationstop 4%

mouseimaging

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NeurosciencebioRxivPreprintMar 14, 2026

HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signaling

Elsa M. Reyes‐Reyes, Dhanalakshmi Chinnasamy, Fabian‐Xosé Fernandez…·Kathleen E. Rodgers

This study shows that HLA-DRB1*15:01 causes age- and sex-dependent microglial activation and neuroimmune signaling changes linked to cognitive impairment and inflammation in the CNS.

DOI 10.64898/2026.03.11.711132

mouseexperimental assay

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