Author

Xiaoya Zhang

University of Wisconsin–MadisonORCID 0000-0002-1614-0011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Rupa SridharaniD· 2 shared Coral K. WilleiD· 1 shared John M. DenuiD· 1 shared Spencer A. HawsiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersMolecular Biology

Rupa SridharanORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 8, 2025

DOT1L induces RNAPII accumulation independent of its catalytic activity in pluripotent stem cells

Xiaoya Zhang, Rupa Sridharan

The paper shows that inducing DOT1L in serum/LIF ESCs increases RNAPII accumulation at transcription start sites, mimicking 2i/LIF conditions, but without altering steady-state RNA expression.

DOI 10.1101/2025.08.08.668971

mousebulk RNA-seq

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Developmental BiologyScience AdvancesPeer-reviewedNov 17, 2023

Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency

Coral K. Wille, Xiaoya Zhang, Spencer A. Haws…·Rupa Sridharan

The paper shows that low H3K79 methylation in ESCs promotes transcription elongation at housekeeping genes, and inhibiting DOT1L enhances iPSC reprogramming by increasing H3K9ac.

17 citations

mouseChIP-seq

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