Author
University of Wisconsin–MadisonORCID 0000-0002-2166-1858Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Kellen Biesbrock, Spencer A. Haws, Harshini Cormaty…·John M. Denu
This study introduces CRISPRm, a dCas9-metabolic enzyme fusion platform, to investigate how nuclear metabolic perturbations affect gene expression and chromatin states in HEK293T cells.
Cassandra M. Leech, Spencer A. Haws, John M. Denu
The paper shows methionine, not SAM, is the primary metabolic signal for chromatin remodeling under stress, with methionine depletion causing epigenetic and transcriptional changes independent of SAM levels.
Coral K. Wille, Xiaoya Zhang, Spencer A. Haws…·Rupa Sridharan
The paper shows that low H3K79 methylation in ESCs promotes transcription elongation at housekeeping genes, and inhibiting DOT1L enhances iPSC reprogramming by increasing H3K9ac.