Author

Coral K. Wille

University of Wisconsin–MadisonORCID 0000-0002-0506-3209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Rupa SridharaniD· 3 shared Aniruddha J. DeshpandeiD· 1 shared Edwin N. NeumanniD· 1 shared John M. DenuiD· 1 shared Spencer A. HawsiD· 1 shared Xiaoya ZhangiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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3 shared papersDevelopmental Biology

Rupa SridharanORCID

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3 papers

Recent·Most cited

DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity

Coral K. Wille, Edwin N. Neumann, Aniruddha J. Deshpande, Rupa Sridharan

The paper shows that AF10, a DOT1L interaction partner, regulates H3K79 methylation levels and RNA polymerase II distribution to maintain cell identity and prevent reprogramming.

Stem Cell Reports · Nov 22, 2023Peer-reviewedDevelopmental Biology

Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotency

Coral K. Wille, Xiaoya Zhang, Spencer A. Haws, John M. Denu, Rupa Sridharan

The paper shows that low H3K79 methylation in ESCs promotes transcription elongation at housekeeping genes, and inhibiting DOT1L enhances iPSC reprogramming by increasing H3K9ac.

Science Advances · Nov 17, 2023Peer-reviewedDevelopmental Biology

Dot1L methyltransferase activity is a barrier to acquisition of pluripotency but not transdifferentiation

Coral K. Wille, Rupa Sridharan

This study shows that inhibiting Dot1L, an H3K79 methyltransferase, enhances reprogramming of somatic cells to iPSCs but does not improve transdifferentiation to neurons or muscle cells.

Stem Cell Reports · Jan 6, 2022Peer-reviewedDevelopmental Biology