Author

Maria Khrestian

Cleveland ClinicORCID 0000-0002-1621-4711Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:proteomics· 3 Research Focus:benchmarking· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Lynn M. BekrisiD· 5 shared James B. LeverenziD· 3 shared Yvonne Y. Shao· 3 shared Elizabeth D. Tuason· 2 shared Grace E. WeberiD· 2 shared Jagan A. PillaiiD· 2 shared Katherine A. KoenigiD· 2 shared Mark J. LoweiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersNeuroscience

Lynn M. BekrisORCID

Mutual co-authors in cluster

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5 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 17, 2026

Association of object mnemonic discrimination deficit with age and AD biomarkers in older adults

Zhengshi Yang, Xiaowei Zhuang, Lynn M. Bekris…·Dietmar Cordes

This study links object mnemonic discrimination to age and AD biomarkers in older adults, finding strong associations with hippocampal volume and pTau217, and comparable diagnostic accuracy to established biomarkers.

DOI 10.64898/2026.09.14.750966

humanstatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 4, 2026

Early peripheral immune signaling precedes tau elevation and blood-brain barrier disruption in Alzheimer's disease

Aaron Burberry, Penelope H. Benchek, Mark J. Lowe…·Jagan A. Pillai

DOI 10.64898/2026.04.02.716122

humanproteomics

𝕏 PostBluesky

NeuroscienceThe Journal of ImmunologyPeer-reviewedMay 1, 2022

Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer's disease

Grace E. Weber, Maria Khrestian, Elizabeth D. Tuason…·Lynn M. Bekris

This study examines the relationship between sTREM2 and inflammatory activity in early stage Alzheimer's disease using clinical and biomarker-defined groups.

20 citations

humanproteomics

𝕏 PostBluesky

Molecular BiologyMolecular ImmunologyPeer-reviewedJan 15, 2021

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells

Rumana Akhter, Yvonne Y. Shao, Shane V. Formica…·Lynn M. Bekris

This study investigates how TREM2 affects the phagocytic, apoptotic, and inflammatory responses to Aβ42 in HMC3 cells, finding TREM2 enhances phagocytosis and inhibits apoptosis and certain inflammatory factors.

69 citations

humanexperimental assay

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NeuroscienceThe Journal of ImmunologyPeer-reviewedJan 20, 2020

Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome

Grace E. Weber, Katherine A. Koenig, Maria Khrestian…·Lynn M. Bekris

This study examines the relationship between soluble TREM2 and inflammatory markers in young adults with Down syndrome compared to neurotypical controls, finding elevated sTREM2 and positive correlations with cytokines in DS.

26 citations

humanproteomics

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