This study links object mnemonic discrimination to age and AD biomarkers in older adults, finding strong associations with hippocampal volume and pTau217, and comparable diagnostic accuracy to established biomarkers.

bioRxiv · Sep 17, 2026 · PreprintNeuroscience

Early peripheral immune signaling precedes tau elevation and blood-brain barrier disruption in Alzheimer's disease

Aaron Burberry, Penelope H. Benchek, Mark J. Lowe, Wanyong Shin, Blake T. McCourt, Quintasha Beamon, Shinjon Chakrabarti, Sara Ramaiah, Elizabeth Woidke, Maria Khrestian, Holden Terry Maecker, Lynn M. Bekris, Stephen M. Rao, Daniel Ontaneda, James B. Leverenz, , Jagan A. Pillai

bioRxiv · Apr 4, 2026 · PreprintNeuroscience

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer Disease Model

Aanishaa Jhaldiyal, Manisha Kumari, Trupti Tripathi, Rizwan Hasan Khan, Justin L. Wang, Lauren C. Guttman, Devanik Biswas, Abhishek Pasupuleti, Akansha Aggarwal, Shraddha Pandya, Shih-Ching Chou, Nikhil Panicker, Abhay Monghekar, Marilyn Albert, Lynn M. Bekris, , Valina Lynn Dawson

This study shows PARP1 inhibition reduces amyloid pathology, neurodegeneration, and cognitive decline in a mouse model of Alzheimer's disease.

bioRxiv · Sep 6, 2025 · PreprintNeuroscience

Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer's disease

Grace E. Weber, Maria Khrestian, Elizabeth D. Tuason, Yvonne Y. Shao, Jagan A. Pillai, Stephen M. Rao, Hao Feng, Yadi Zhou, Feixiong Cheng, Tara M. DeSilva, Shaun R. Stauffer, James B. Leverenz, Lynn M. Bekris

This study examines the relationship between sTREM2 and inflammatory activity in early stage Alzheimer's disease using clinical and biomarker-defined groups.

The Journal of Immunology · May 1, 2022Peer-reviewedNeuroscience

Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

Jielin Xu, Pengyue Zhang, Yin Huang, Yadi Zhou, Yuan Hou, Lynn M. Bekris, Justin Durla Lathia, Chien‐Wei Chiang, Lang Li, Andrew A. Pieper, James B. Leverenz, Jeffrey L. Cummings, Feixiong Cheng

Genome Research · Feb 24, 2021Peer-reviewedNeuroscience

TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells

Rumana Akhter, Yvonne Y. Shao, Shane V. Formica, Maria Khrestian, Lynn M. Bekris

This study investigates how TREM2 affects the phagocytic, apoptotic, and inflammatory responses to Aβ42 in HMC3 cells, finding TREM2 enhances phagocytosis and inhibits apoptosis and certain inflammatory factors.

Molecular Immunology · Jan 15, 2021Peer-reviewedMolecular Biology

AlzGPS: A Genome-wide Positioning Systems Platform to Catalyze Multi-omics for Alzheimer's Therapeutic Discovery

Yadi Zhou, Jiansong Fang, Lynn M. Bekris, Young Heon Kim, Andrew A. Pieper, James B. Leverenz, Jeffrey L. Cummings, Feixiong Cheng

AlzGPS integrates multi-omics data and networks to identify repurposable drugs for Alzheimer's disease.

Alzheimer s Research & Therapy · Jan 13, 2021Peer-reviewedSystems Biology

Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome

Grace E. Weber, Katherine A. Koenig, Maria Khrestian, Yvonne Y. Shao, Elizabeth D. Tuason, Marie Gramm, Dennis Lal, James B. Leverenz, Lynn M. Bekris

This study examines the relationship between soluble TREM2 and inflammatory markers in young adults with Down syndrome compared to neurotypical controls, finding elevated sTREM2 and positive correlations with cytokines in DS.

The Journal of Immunology · Jan 20, 2020Peer-reviewedNeuroscience