James B. Leverenz

Genome-wide association study of copy number variations in Parkinson's disease

This study conducts a genome-wide association study of copy number variations in Parkinson's disease, identifying a significant PRKN deletion but limited replication in an independent dataset.

Early peripheral immune signaling precedes tau elevation and blood-brain barrier disruption in Alzheimer's disease

Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer Disease Model

This study shows PARP1 inhibition reduces amyloid pathology, neurodegeneration, and cognitive decline in a mouse model of Alzheimer's disease.

Comprehensive characterization of multi-omic landscapes between gut-microbiota metabolites and the G-protein-coupled receptors in Alzheimer's disease

This study identifies GPCR targets of gut microbiota metabolites in Alzheimer's disease using multi-omics and machine learning.

Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer's disease

This study examines the relationship between sTREM2 and inflammatory activity in early stage Alzheimer's disease using clinical and biomarker-defined groups.

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

This study links SARS-CoV-2 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment through network-based genomics analysis.

Multimodal single-cell/nucleus RNA-sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

AlzGPS: A Genome-wide Positioning Systems Platform to Catalyze Multi-omics for Alzheimer's Therapeutic Discovery

AlzGPS integrates multi-omics data and networks to identify repurposable drugs for Alzheimer's disease.

Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome

This study examines the relationship between soluble TREM2 and inflammatory markers in young adults with Down syndrome compared to neurotypical controls, finding elevated sTREM2 and positive correlations with cytokines in DS.

Analysis of shared heritability in common disorders of the brain

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.