Author

Rapolas Spalinskas

Science for Life LaboratoryORCID 0000-0002-1648-6426Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:fine-mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Pelin SahléniD· 2 shared Per Olof ErikssoniD· 2 shared Sailendra PradhanangaiD· 2 shared Anandashankar Anil· 1 shared Anders Franco‐CerecedaiD· 1 shared Andrey BuyaniD· 1 shared Anne BonniniD· 1 shared Artemy ZhiguleviD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Pelin SahlénORCID

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3 papers

Recent·Most cited

Efficient murine cardiac phenotyping by combining synchrotron-based phase-contrast micro-CT, histology, immunofluorescence and spatial transcriptomics

Niccolò Peruzzi, Ayse Ceren Mutgan, Kinga I. Gawlik, Timothy J. Mead, Tuva Jerlhagen Forsgren, Elin Lagervall, Till Dreier, Robin Krüger, Elna Lampei, Jenny Romell, Rapolas Spalinskas, Madeleine Durbeej, Suneel Apte, Martin Bech, Anne Bonnin, , Karin Tran‐Lundmark

The paper combines SRPC-microCT with spatial transcriptomics and histology to enable 3D cardiac phenotyping in mice, linking structural and molecular data.

bioRxiv · Apr 28, 2026 · PreprintDevelopmental Biology

Rare gain-of-function regulatory mutations explain the missing heritability of bicuspid aortic valve

Artemy Zhigulev, Andrey Buyan, Enikő Lázár, Nikita Gryzunov, Karin Lång, Raphaël Mauron, Vladimir Nozdrin, Rapolas Spalinskas, Sailendra Pradhananga, Madeleine Petersson Sjögren, Doreen Schwochow, Anders Franco‐Cereceda, Joakim Lundeberg, Ivan V. Kulakovskiy, Per Eriksson, , Pelin Sahlén

The paper identifies rare gain-of-function regulatory mutations as significant contributors to the missing heritability of bicuspid aortic valve.

Nature Communications · Apr 18, 2026Peer-reviewedGenetic & Genomic Medicine

High-resolution regulatory maps connect cardiovascular risk variants to disease related pathways

Örjan Åkerborg, Rapolas Spalinskas, Sailendra Pradhananga, Anandashankar Anil, Pontus Höjer, Flore-Anne Poujade, Lasse Folkersen, Per Olof Eriksson, Pelin Sahlén

This study connects cardiovascular risk variants to disease-related pathways using high-resolution genomic interaction maps in relevant cell types.

bioRxiv · Jul 24, 2018 · PreprintGenomics