Harald H.H.W. Schmidt

This paper introduces a Nextflow pipeline to evaluate disease module detection methods, showing variability in results due to method, network, and seed differences.

This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.

This study identifies Trp324 nitration in lactate dehydrogenase as a physiological signaling mechanism modulating enzyme activity under metabolic stress.

This study identifies NOX5 as a key mediator of calcium-dependent reactive oxygen species formation and blood-brain barrier breakdown after reperfusion in stroke, suggesting NOX inhibition as a potential therapeutic strategy.

This study introduces PxEA, a network-based method to identify drugs targeting common pathways across diseases, demonstrating drug repurposing opportunities for autoimmune disorders and comorbid conditions like type 2 diabetes and Alzheimer's disease.