Cancer BiologybioRxivPreprint
Genomic alterations enable BRCA1 methylation loss and promoter bypass to drive resistance in high-grade serous ovarian cancer
Longyun Xu, Ksenija Nesic, Sally Beard…·Olga Kondrashova
This study identifies genomic mechanisms enabling BRCA1 methylation loss and promoter bypass in ovarian cancer, leading to PARP inhibitor resistance.
DOI 10.64898/2026.07.28.740856